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Amikacin sulfate

Item	Specification
Identifications	Positive
Specific rotation	+76°-+84°
Crystallinity	conforms
pH	pH6.0-7.3
Loss on drying	Max13%
Residue on ignition	Max1.0%
Assayof amikacin C22H43N5O13	691-806ug/mg
Calculated on the dried basis by HPLC
Sterility	Conforms

Conclusion         Comply with the USP32

Storage            Store in cool & dry place, stored in well-closed containers 

Shelf Life          3 years when properly stored

 [ chemically : D-Streptamine, O-3-amino-3-deoxy-alpha-D- glucopyranosyl- (1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))- N1-(4-amino-2-hydroxy-1- oxobutyl)- 2-deoxy-, (S)-sulfate (1:2) (salt)] is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. Its spectrum is somewhat broader than that of other aminoglycosides, including Serratia and Acinetobacter species, as well as certain staphylococci and streptococci. It is the most effective agent against gram-negative bacilli that have some aminoglycoside resistance. It is used for the treatment of serious infections resistant to gentamicin and tobramycin (bone infections, respiratory tract infections, endocarditis, and septicemia).

Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit and in some cases the 50S subunit, causing miscoding and thus inhibiting initiation and elongation during protein synthesis.

Veterinary antibiotics