... Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then ... a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial ... veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used ...